 |
| |
 |
ALBENDAZOLE
Mechanism of Action
Albendazole exhibits a broad-spectrum anthelmintic activity showing vermicidal, ovicidal and larvicidal actions. It inhibits tubulin polymerization in the parasite and blocks glucose uptake; energy levels are reduced resulting to death of the parasite. Susceptible parasites include hookworm, roundworm, threadworm, whipworm, tapeworm, strongyloides, opisthorchis and hydatid disease (Echinococcus).
Absorption: Poorly absorbed from the GI tract (oral).
Distribution: Widely distributed; bile, CSF. Protein-binding: 70%
Metabolism: Extensive hepatic first-pass metabolism; converted to albendazole sulfoxide.
Excretion: Via bile; via urine (small amounts). 8.5 hr (elimination half-life).
MIMS Class: Anthelmintics
ATC Classification:
P02CA03 - albendazole; Belongs to the class of benzimidazole derivative agents.
Used as antinematodal. |
| |
| Reference: mims |
|
|
 |
 |
Watch out for our new products. Coming out soon. |
|
| |
|
